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Therapeutic Expertise |
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Metabolic & Infectious Diseases (HIV) |
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Image Acquisition Aids
SynaFlexer™ Frame and Phantom
SynaFlexer™ Frame and Phantom is a knee positioning device.
Radiographic joint-space width as an indirect measure of articular cartilage thickness is currently the primary structural endpoint used in clinical trials of osteoarthritis of the knee and hip. Most of the variation associated with serial joint-space width measurements in clinical trials is introduced during image acquisition. Minimizing this source of variation is therefore the key to effective multi-center radiography.
The principal sources of variability in radiography of the knee and hip are:
- Joint positioning (flexion, rotation)
- Beam centering and angulation
- Geometric magnification
- Parallax error
These potential sources of measurement error are controlled and corrected with the SynaFlexer™positioning frame and phantom. SynaFlexer™ is a specialized image-acquisition aid developed by our experts Charles Peterfy, MD, PhD and David White, PhD. Over the past several years, thousands of knee radiographs have been acquired for multicenter studies of osteoarthritis using the SynaFlexer™ system.
SynaFlexer™ Frame and Phantom
The SynaFlexer™ frame is constructed of lightweight Plexiglas, and allows convenient, reproducible positioning of the knee or hip without the need for foot-maps regardless of the radiographic technique(fixed-flexion, semi-flexed MTP, and conventional extended).
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